Speaking of newer cosmetic uses of drugs, many readers may not be aware that the some of the original uses of Botox also were in ophthalmology. The muscle paralyzing properties were and continue to be used in blepharospasm, a benign but very disturbing forceful lid closing condition. Patients who suffer from blepharospasm experience uncontrolled forceful lid closure/spasms that can be quite debilitating. The injection of botox in and around the eyelids can give relief for approximately 6 months. Now the most common use of Botox is the relaxation of facial wrinkles. Newer indications continue to evolve and Botox has been used for relief of other muscle spasms and contractions, strabismus, severe sweating (hyperhidrosis), and headaches.